Drugs Metabolism & Pharmacokinetics (DMPK)

  • Physicochemical Screening (Solubility, Stability, LogD and LogP)
  • Bio relevant Solubility studies
  • Plasma Stability studies
  • Plasma Protein Binding
  • Permeability studies
  • Metabolic Stability
  • Drug-Drug Interaction (CYP inhibition and induction, CYP450 Reaction Phenotyping)
  • Metabolite ID and profiling
  • Single/Multiple dose Pharmacokinetics
  • Cassette (N-in-one) Pharmacokinetics
  • Drug Distribution in Tissue/Body Fluids
  • Blood brain barrier studies
  • Metabolite Identification/Quantitation – plasma, urine & brain
  • PK/PD relationship studies
  • Toxicokinetics with Bioanalysis for Exploratory Toxicity Studies


Our Bioanalytical capabilities include proprietary method development, validation, method transfer, high throughput sample analysis and pharmacokinetic and toxicokinetic Bioanalysis.
Expert bioanalysis support for both small molecule and biologic molecules drugs is provided through our network and collaboration of state-of-the-art, GLP and Non-GLP compliant laboratories located in India and abroad.
Recognizing the critical role bioanalysis plays in drug development, Panacea Nova's only effort is to consistently deliver accurate and reliable data on-time that is subject to rigorous scientific and regulatory review to ensure the success of discovery programs.
Bioanalytical Services for Preclinical Research :

  • The Bioanalytical services include end to end solutions in bioanalysis
  • Fit to purpose method development
  • Method validation
  • Bioanalysis of different tissues & Biological matrices
  • LC-MS/MS Bioanalytical Support GLP/Non-GLP
  • High Throughput analysis


Panacea Nova conducts in vivo preclinical pharmacological research from the screening phase till proof of concept studies. We work in close cooperation with our client which is essential in the early phases of development.

  • Efficacy models
  • Inflammation models
  • Autoimmune disorders
  • Pain models
  • Metabolic disorders
  • CNS models
  • Growth hormone and growth factors
  • Wound healing
  • Surgical preparations
  • Customized models

One of the strengths of Panacea Nova is customization of model as per client specific requirement. Highly skilled and qualified veterinarians and life science scientists take special requests from clients into consideration and are able to develop and standardize models to the level of customer satisfaction.


  • Maximum tolerated Dose (MTD)
  • Dose range finding (DRF)
  • Tolerability studies
  • Sub-acute toxicity studies (7, 14, 21 & 28 days)
  • Metabolic disorders
  • Acute Toxicology
  • Repeated dose sub acute & sub chronic toxicity
  • Reproductive toxicity
  • Developmental toxicity
  • Biochemistry & Histopathology
  • Genotox studies


  • Antibiotic sensitivity test
  • Resistance test
  • Preservation Efficacy Test (PET)
  • Sterility Test
  • Microbial Limit Test (MLT)
  • Time Kill Assay